By Steven L. Gersen PhD (auth.), Steven L. Gersen PhD, Martha B. Keagle MEd (eds.)
During this completely revised and improved version of a hugely praised vintage, the rules of scientific Cytogenetics, a panel of hands-on specialists replace their survey of the elemental strategies and interpretations fascinated with chromosome research to incorporate the various advances that experience happened within the box. one of the highlights are an entire part dedicated to advances in fluorescence in situ hybridization (FISH) expertise, elevated insurance of melanoma cytogenetics-both hematopoietic neoplasms and tumor cytogenetics-and new chapters on chromosome instability and the cytogenetics of infertility. The booklet additionally displays significant advances in instrumentation and the transition from FAB to international overall healthiness association nomenclature for hematopoietic issues.
cutting-edge and conveniently obtainable, the rules of medical Cytogenetics, second version deals physicians who depend upon the cytogenetics laboratory for the prognosis in their sufferers, scholars in cytogenetics courses, and cytogeneticists the transparent knowing they should perform and interpret their attempt effects quickly.
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Extra resources for The Principles of Clinical Cytogenetics
Meiosis II The cells move directly from telophase I to metaphase II with no intervening interphase or prophase. Meiosis II proceeds much like mitotic cell division except that each cell contains only 23 chromosomes (see Fig. 12). The 23 chromosomes line up on the equatorial plate in metaphase II, the chromatids separate and move to opposite poles in anaphase II, and cytokinesis occurs in telophase II. The net result is four cells, each of which contains 23 chromosomes, each consisting of a single chromatid.
Dividing cells are needed in order to study chromosomes using traditional cytogenetic techniques, and many cytogenetic abnormalities result from errors in cell division. There are two types of cell division: mitosis and meiosis. Mitosis is the division of somatic cells, whereas meiosis is a special type of division that occurs only in gametic cells. The Cell Cycle The average mammalian cell cycle lasts about 17–18 hours and is the transition of a cell from one interphase through cell division and back to the interphase (21).
1974) Repetitious and unique sequences in the heterogeneous nuclear and cytoplasmic messenger RNA of mammalian and insect cells. Cell 3, 23–30. C. (1979) Human and Mammalian Cytogenetics: An Historical Perspective. Springer-Verlag, New York. F. S. (1987) Hierarchal order in chromosome-specific human alpha satellite DNA. Trends Genet. 3, 192–198. F. (1990) Centromeres of mammalian chromosomes. Trends Genet. 6, 410–416. F. (1982) SINEs and LINEs: highly repeated short and long interspersed sequences in mammalian genomes.
The Principles of Clinical Cytogenetics by Steven L. Gersen PhD (auth.), Steven L. Gersen PhD, Martha B. Keagle MEd (eds.)