By Sebastian Fischer, Matthias Schulte, Tobias Hirsch, Marcus Lehnhardt, Björn Behr (auth.), M.A. Hayat (eds.)
Presenting contributions through sixty six specialists representing thirteen nations, quantity 10 of the sequence Stem Cells and melanoma Stem Cells synthesizes present figuring out of the explanations, prognosis, and treatment of significant human illnesses and debilitating tissue and organ accidents, utilizing cell-based remedy. This quantity provides modern study into new release, upkeep, and makes use of of stem cells in scuffling with ailment and tissue/organ injuries.
The contents of the amount are geared up into 5 sections. Mesenchymal Stem Cells part contains chapters at the use of stem cells in bone regeneration, reports and trials of stem cells in autoimmune illnesses, and variations among adipose tissue-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells as regulators of immune reaction. precipitated Pluripotent Stem Cells part bargains chapters on drug discovery utilizing human IPSC-based affliction types, and on new release of antigen-specific lymphocytes from IPSCs. Neural Cells and Neural Stem Cells part discusses use of bacterial synthetic chromosomes within the genetic id of stem cell-derived neural mobile kinds, and use of average low temperature to maintain the stemness of neural stem cells. The part, position of Stem Cells in disorder, discusses stem phone help in high-dose chemotherapy of Non-Hodgkin’s Lymphomas; strength goals for drug resistant leukemic stem cells, bone marrow stem telephone remedies for diabetes mellitus. This part additionally discusses using stem cells in treating thyroid, breast and bone cancers, hempophilia and Parkinson’s affliction. The part, Stem cellphone Transplantation, comprises chapters on decreasing fungal an infection in allogenic stem cellphone transplantation sufferers, use of Bulsufan/Fludarabine for conditioning in haematopoietic stem telephone transplantation, and interleukin-7 receptor alpha polymorphisms in allogeneic stem mobilephone transplantation.
The editor, M.A. Hayat, is a uncommon Professor within the division of organic, Sciences at Kean college, Union, New Jersey, USA.
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Extra info for Stem Cells and Cancer Stem Cells, Volume 10: Therapeutic Applications in Disease and Injury
6 Sources of Mesenchymal Stem Cells . . . . . . . . 7 Clinical Use . . . . . . . . . . . . . . . . . . . . . . 8 Future Directions . . . . . . . . . . . . . . . . . . 9 References . . . . . . . . . . . . . . . . . . . . . . 10 Since the discovery that certain bone marrow cells are capable of ectopic bone formation in 1963, scientists scented new therapeutic strategies to overcome clinical problems of bone defects unable to heal or fuse spontaneously.
14 Experimental Animal Models of Autoimmune Diseases . . . . . . . . . . . . . . . . . . . . . . . . 15 Therapeutic Application of Adipose Tissue-Derived Mesenchymal Stem Cells in Experimental Animal Models of Autoimmune Diseases . . . . . . . . . . . . . . . . . . . . . . . . 16 Clinical Trials of Adipose Tissue-Derived Mesenchymal Stem Cells to Treat Autoimmune Diseases . . . . . . . . . . . . . . . . . . . . . .
Due to this capacity, MSCs were utilized for tissue engineering purposes to overcome impaired healing of bone defects, which are otherwise unable to heal or fuse despite adequate treatment. Combined with growth factors and scaffolds, MSCs may accelerate, enhance or even replace endogenous bone formation, assuring its regenerative potential. The following chapter should give an insight into the role of MSCs in the complex biology of bone regeneration as well as their therapeutic utilization regarding current tissue engineering principles and future directions.
Stem Cells and Cancer Stem Cells, Volume 10: Therapeutic Applications in Disease and Injury by Sebastian Fischer, Matthias Schulte, Tobias Hirsch, Marcus Lehnhardt, Björn Behr (auth.), M.A. Hayat (eds.)