New PDF release: Proteomics in Drug Research

By Michael Hamacher, Katrin Marcus, Kai Stühler, Andre van Hall, Bettina Warscheid, Helmut E. Meyer, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

ISBN-10: 3527312269

ISBN-13: 9783527312269

From skillful dealing with of the wide variety of applied sciences to profitable purposes in drug discovery—this instruction manual has all of the info expert proteomics clients desire.

Edited via specialists operating at one of many scorching spots in ecu proteomic examine, the various contributions via specialists from the pharmaceutical and public proteomics consortia to supply the mandatory standpoint on present traits and advancements during this intriguing box.

Following an introductory bankruptcy, the publication strikes directly to proteomic applied sciences, resembling protein biochips, protein-protein interactions, and proteome research in situ. The part on functions comprises bioinformatics, Alzheimer's affliction, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome research and biomarkers, in addition to pharmacogenomics.

precious analyzing for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and people operating within the pharmaceutical undefined.

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Additional info for Proteomics in Drug Research

Sample text

HUPO is also contributing to the establishment of large-scale data sets for a number of human tissues of particular interest in the pathogenesis of disease. The aim of these initiatives is to produce comprehensive lists of proteins present in normal plasma, liver and brain, whilst identifying regional and racial variants within the population. All three project groups have acquired samples from large cohorts of donors which are currently being analyzed in laboratories across the world by a standard set of procedures.

F. (1981). Towards a total human protein map. Nature 292, 491–491. , Muller, G. (2004). Evaluation of kinase inhibitor selectivity by chemical proteomics. Assay Drug Dev. Technol. 2, 215–224. , Sigrist, C. J. , Bairoch, A. (2002). The PROSITE database, its status in 2002. Nucleic Acids Res. 30, 235–238. Haft, D. , Selengut, J. , White, O. (2003). The TIGRFAMs database of protein families. Nucleic Acids Res. 31, 371–373. Harris, M. , et al. (2004). The Gene Ontology (GO) database and informatics resource.

Cell Proteomics 3, 298–301. , Grant, S. , Apweiler, R. (2004a). The HUPO PSI’s molecular interaction format – a community standard for the representation of protein interaction data. Nat. Biotechnol. 22, 177–183. , Apweiler, R. (2004b). IntAct: an open source molecular interaction database. Nucleic Acids Res. 32, D452–D455. Humphery-Smith, I. (2004). A human proteome project with a beginning and an end. Proteomics 4, 2519–2521. , Imamura, M. (2004). Survivin expression is a prognostic marker in pancreatic cancer patients.

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Proteomics in Drug Research by Michael Hamacher, Katrin Marcus, Kai Stühler, Andre van Hall, Bettina Warscheid, Helmut E. Meyer, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

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