By Johannes Buchner, Thomas Kiefhaber
This exact guide comprises the services from greater than 60 examine teams, masking the total diversity of themes in protein folding - from biophysics to molecular medication. the 1st half explains the foundations and elements governing protein balance, and the way this data can be utilized to foretell folding pathways. It additionally surveys vital concepts used to check the protein folding technique, together with spectroscopic, chemical and organic options. the second one half is dedicated to protein folding, unfolding, and misfolding within the mobile context, introducing chaperones and different enzymes serious about protein folding, in addition to a research of the pathophysiology of misfolded proteins in amyloid and different sickness states. the full is rounded off by means of a dialogue of the potential for interfering with the protein folding method through genetic engineering. The comprehensiveness and impressive caliber of the conscientiously chosen contents make this the last word reference for each scientist with an curiosity in protein folding.
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Extra info for Protein Folding Handbook
McClintock Ave. Los Angeles, CA 90089-1062 USA Heiko Carstens Department fu¨r Physik Ludwig-Maximilians-Universita¨t Mu¨nchen Oettingenstrasse 67 80538 Mu¨nchen Germany Hong Cheng Basic Science Division Fox Chase Cancer Center 333 Cottman Avenue Philadelphia, PA 19111 USA Jane Clarke University Chemical Laboratories MRC Centre for Protein Engineering Lensﬁeld Road Cambridge CB2 1EW United Kingdom Monika Davidovic Department of Biophysical Chemistry Lund University 22100 Lund Sweden Contributors Vladimir P.
6 LVIII Paradigm Changes from ‘‘Unboiling an Egg’’ to ‘‘Synthesizing a Rabbit’’ 3 Rainer Jaenicke Protein Structure, Stability, and Self-organization 3 Autonomous and Assisted Folding and Association 6 Native, Intermediate, and Denatured States 11 Folding and Merging of Domains – Association of Subunits Limits of Reconstitution 19 In Vitro Denaturation-Renaturation vs. 2 Perspectives 24 Acknowledgements References 26 26 Folding and Association of Multi-domain and Oligomeric Proteins Hauke Lilie and Robert Seckler Introduction 32 Folding of Multi-domain Proteins 33 Domain Architecture 33 g-Crystallin as a Model for a Two-domain Protein 35 The Giant Protein Titin 39 Folding and Association of Oligomeric Proteins 41 Why Oligomers?
The Protein Folding Handbook takes a diﬀerent approach as it combines in-depth reviews with detailed experimental protocols. Thus, a comprehensive, multi-faceted view of the entire ﬁeld of protein folding from basic physical principles to molecular chaperones, protein folding diseases and the biotechnology of protein folding – is presented. The Protein Folding Handbook intends to provide those who become interested in a speciﬁc aspect of protein folding with both the scientiﬁc background and the experimental approaches.
Protein Folding Handbook by Johannes Buchner, Thomas Kiefhaber