Ton J. Cleophas M.D., Ph.D (auth.)'s Human Experimentation: Methodologic issues fundamental to PDF

By Ton J. Cleophas M.D., Ph.D (auth.)

ISBN-10: 0792358279

ISBN-13: 9780792358275

ISBN-10: 9401146632

ISBN-13: 9789401146630

Despite their effectiveness within the assessment of latest pharmacological compounds, managed scientific trials are often insufficient. utilizing info from the literature in addition to from the author's personal event with scientific trials, Human Experimentation: Methodologic concerns primary to scientific Trials addresses such inadequacies and attempts to supply strategies. This paintings is the 1st to completely study those unsolved inadequacies and issues of the layout and the execution of scientific trials and, extra importantly, to supply ideas for those difficulties. it's important for a person who's all for scientific learn: clinicians, pharmacists, biochemists, statisticians, nurses, sponsors, etc., and somebody who's thinking about utilizing result of study to sufferers, i.e. physicians.

Show description

Read or Download Human Experimentation: Methodologic issues fundamental to clinical trials PDF

Similar clinical books

Read e-book online Breast Cancer: Biological and Clinical Progress: Proceedings PDF

The struggle opposed to breast melanoma is anticipated to be successfully motivated through interdisciplinary techniques and cross-fertilization among laboratory and scientific learn findings. Of significant significance are consequently conferences selling quick move to scientific functions of findings by means of uncomplicated scientists.

Get Cardiac Glycosides: Part II: Pharmacokinetics and Clinical PDF

The pharmacokinetics of digitalis glycosides were the topic of in depth re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai. , 1977). learn on glycoside kinetics has advanced at a fast velocity, requiring carrying on with reevaluation of the country of our knowing of this challenge. the current article specializes in the impact of disorder states (renal, gastrointestinal, thyroid, and cardiac) at the absorption, distribution, and clearance of a couple of digitalis glycosides.

Download e-book for iPad: Clinical Glaucoma Care: The Essentials by Nils A. Loewen MD, PhD, Angelo P. Tanna MD (auth.), John R.

Glaucoma scientific Care: The necessities is a realistic, slimmer better half quantity to the extra academically centred textual content “The Glaucoma e-book” by means of an identical editors. This new booklet is a completely up to date guide for the daily analysis and administration of glaucoma sufferers via accomplished ophthalmologists and optometric physicians.

Extra info for Human Experimentation: Methodologic issues fundamental to clinical trials

Sample text

Palliative care is considered to be different from symptom-based management in that the former is supposed to deal with issues in the management of terminally ill and the latter is related to a variety of ailments suffered by the person [14]. The hospice literature usually embraces the former and no literature by and large has taken up the latter. Also, quality of life studies are considered to be different [15,16]. Although they focus on symptoms and adverse effects,they do so in the context of treatments given for indications other than the relief of such symptoms, for example, the remission of cancer, or the reduction of blood pressure.

2. In other study designs no test is available. So, clinical arguments and alertness for unexpected patterns in the data are the only defenses against it so far. 3. Dose response, dose titration, and open evaluation studies should require sufficient washout periods between the administrations of the drugs. Even 14 plasma halftimes may be required. 4. Studies using of duplicate standard deviations should always be combined with a statistical test for differences between the duplicate data. If a significant difference is detected, the use of duplicate standard deviations for the estimation of intra-individual reproducibility has little value.

Does this mean that they are a failure? In a sense it does. At least such studies do not confirm our prior beliefs, which was the main reason for performing the study in the first place. If the data do not allow to reject the null hypothesis of no treatment effect compared to control we have to think hard about something that may have gone wrong. For example, 1) samples were too small, 2) biases may have entered the study, 3) study designs may have been inappropriate. The present paper focuses on a particular aspect of study designs that may be sometimes inappropriate.

Download PDF sample

Human Experimentation: Methodologic issues fundamental to clinical trials by Ton J. Cleophas M.D., Ph.D (auth.)


by Edward
4.4

Rated 4.05 of 5 – based on 26 votes