By Liv Storstein (auth.), Professor Dr. med. Kurt Greeff (eds.)
The pharmacokinetics of digitalis glycosides were the topic of intensive re view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). study on glycoside kinetics has advanced at a fast speed, requiring carrying on with reevaluation of the kingdom of our figuring out of this challenge. the current article specializes in the impression of ailment states (renal, gastrointestinal, thyroid, and cardiac) at the absorption, distribution, and clearance of a few digitalis glycosides. facts is seriously reviewed, and interpreted with appreciate to attainable medical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in just reports. KRAMER et ai. (1970) made up our minds an removal half-life of 14 h in normals as com pared to 60 h in anuric sufferers. comparable effects have been pronounced through BRASS and Pm LIPPS (1970) utilizing tritiated strophanthin. they discovered a half-life price of 18 h in fit members compared to sixty eight h in anuric sufferers. The findings basically in dicate that the removal half-life of strophanthin is lengthy in renal failure.
Read or Download Cardiac Glycosides: Part II: Pharmacokinetics and Clinical Pharmacology PDF
Best clinical books
The struggle opposed to breast melanoma is predicted to be successfully encouraged by way of interdisciplinary methods and cross-fertilization among laboratory and scientific study findings. Of significant significance are as a result conferences selling speedy move to scientific functions of findings by means of simple scientists.
The pharmacokinetics of digitalis glycosides were the topic of in depth re view (IISALO, 1977; ARONSON, 1980; PERRIER et ai. , 1977). learn on glycoside kinetics has stepped forward at a speedy velocity, requiring carrying on with reevaluation of the nation of our knowing of this challenge. the current article makes a speciality of the impact of illness states (renal, gastrointestinal, thyroid, and cardiac) at the absorption, distribution, and clearance of a couple of digitalis glycosides.
Glaucoma scientific Care: The necessities is a realistic, slimmer better half quantity to the extra academically concentrated textual content “The Glaucoma publication” by way of an analogous editors. This new ebook is a completely up to date guide for the day by day prognosis and administration of glaucoma sufferers by way of entire ophthalmologists and optometric physicians.
- Lipid Absorption: Biochemical and Clinical Aspects: Proceedings of an International Conference held at Titisee, The Black Forest, Germany, May 1975
- Progress in Basic and Clinical Immunology
- Clinical Nephrotoxins
- Advances in Controlled Clinical Inhalation Studies
- Clinical Pharmacology in the Elderly: Reference Ranges and Biological Variations After Repeated Measurements
Additional resources for Cardiac Glycosides: Part II: Pharmacokinetics and Clinical Pharmacology
J. Med. : The tissue distribution and excretion ofradioactive digitoxin. : Konzentration von Herzglykosiden im Myokard und im Gehirn. Arzneim. Forsch. : Affinitiit von polaren Digoxin- und Digitoxin-MetaboIiten zu Digoxin- und Digitoxin-Antikorpern. Arzneim. Forsch. : The onset and magnitude of the contractile response to commonly used glycosides in normal subjects. , S1. : The behavior and fate of digitoxin in the experimental animal and man. : The uptake and content of digitoxin and its metabolites in the heart muscle in guinea-pigs after acute and chronic application.
0043 mg· kg- 1 . 0031 mg' kg - 1 . day - 1. These findings support the concept of a higher maintenance dosage in infants than in children. The digitoxin concentrations measured by GIARDINA et al. (1975) in pediatric patients were significantly higher than in adults. Toxicity in a small number of infants and children was associated with serum digitoxin concentrations in the range 50-85 ng/ml, the values being higher than toxic concentrations observed in adults. These data indicate that children tolerate higher serum digitoxin levels before exhibiting symptoms or signs of digitoxin toxicity.
Increased fecal excretion was demonstrated by VOHRINGER et al. (1976). We have studied the metabolic pattern of cardioactive and inactive conjugated metabolites of digitoxin in serum and urine in uremic patients on maintenance treatment with the drug and compared these results with data from control subjects (Fig. 7). Uremic patients had less unchanged digitoxin and more hydroxylated and hydrolyzed metabolites than the control group whereas the extent of conjugation was the same in the two groups (STORSTEIN, 1977c).
Cardiac Glycosides: Part II: Pharmacokinetics and Clinical Pharmacology by Liv Storstein (auth.), Professor Dr. med. Kurt Greeff (eds.)