Read e-book online Cardiac Glycosides: Part II: Pharmacokinetics and Clinical PDF

By Liv Storstein (auth.), Professor Dr. med. Kurt Greeff (eds.)

ISBN-10: 3642681662

ISBN-13: 9783642681660

ISBN-10: 3642681689

ISBN-13: 9783642681684

The pharmacokinetics of digitalis glycosides were the topic of intensive re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). study on glycoside kinetics has advanced at a fast speed, requiring carrying on with reevaluation of the kingdom of our figuring out of this challenge. the current article specializes in the impression of ailment states (renal, gastrointestinal, thyroid, and cardiac) at the absorption, distribution, and clearance of a few digitalis glycosides. facts is seriously reviewed, and interpreted with appreciate to attainable medical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in just reports. KRAMER et ai. (1970) made up our minds an removal half-life of 14 h in normals as com­ pared to 60 h in anuric sufferers. comparable effects have been pronounced through BRASS and Pm­ LIPPS (1970) utilizing tritiated strophanthin. they discovered a half-life price of 18 h in fit members compared to sixty eight h in anuric sufferers. The findings basically in­ dicate that the removal half-life of strophanthin is lengthy in renal failure.

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Cardiac Glycosides: Part II: Pharmacokinetics and Clinical - download pdf or read online

The pharmacokinetics of digitalis glycosides were the topic of in depth re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai. , 1977). learn on glycoside kinetics has stepped forward at a speedy velocity, requiring carrying on with reevaluation of the nation of our knowing of this challenge. the current article makes a speciality of the impact of illness states (renal, gastrointestinal, thyroid, and cardiac) at the absorption, distribution, and clearance of a couple of digitalis glycosides.

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J. Med. : The tissue distribution and excretion ofradioactive digitoxin. : Konzentration von Herzglykosiden im Myokard und im Gehirn. Arzneim. Forsch. : Affinitiit von polaren Digoxin- und Digitoxin-MetaboIiten zu Digoxin- und Digitoxin-Antikorpern. Arzneim. Forsch. : The onset and magnitude of the contractile response to commonly used glycosides in normal subjects. , S1. : The behavior and fate of digitoxin in the experimental animal and man. : The uptake and content of digitoxin and its metabolites in the heart muscle in guinea-pigs after acute and chronic application.

0043 mg· kg- 1 . 0031 mg' kg - 1 . day - 1. These findings support the concept of a higher maintenance dosage in infants than in children. The digitoxin concentrations measured by GIARDINA et al. (1975) in pediatric patients were significantly higher than in adults. Toxicity in a small number of infants and children was associated with serum digitoxin concentrations in the range 50-85 ng/ml, the values being higher than toxic concentrations observed in adults. These data indicate that children tolerate higher serum digitoxin levels before exhibiting symptoms or signs of digitoxin toxicity.

Increased fecal excretion was demonstrated by VOHRINGER et al. (1976). We have studied the metabolic pattern of cardioactive and inactive conjugated metabolites of digitoxin in serum and urine in uremic patients on maintenance treatment with the drug and compared these results with data from control subjects (Fig. 7). Uremic patients had less unchanged digitoxin and more hydroxylated and hydrolyzed metabolites than the control group whereas the extent of conjugation was the same in the two groups (STORSTEIN, 1977c).

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Cardiac Glycosides: Part II: Pharmacokinetics and Clinical Pharmacology by Liv Storstein (auth.), Professor Dr. med. Kurt Greeff (eds.)


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