Get Cancer Immunotherapy: Paradigms, Practice and Promise PDF

By Tyler J. Curiel (auth.), Tyler J. Curiel (eds.)

ISBN-10: 1461447313

ISBN-13: 9781461447313

ISBN-10: 1461447321

ISBN-13: 9781461447320

This paintings will offer a historic viewpoint on tumor immunotherapy, speak about basic mechanisms of failed tumor rejection, examine passive options to spice up anti-tumor immunity, in addition to have an in-depth examine energetic suggestions to spice up anti-tumor immunity.

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Extra info for Cancer Immunotherapy: Paradigms, Practice and Promise

Sample text

Killer (NK), and T cell function133, 134; competitive consumption of the T cell survival factor IL-2119, 135, 136; perforin and granzyme-dependent killing of APCs and T cells137, 138; CTLA-4 induction of indolamine 2,3-dioxygenase (IDO)-expression, which promotes tolerance139–141; and finally induction of B7H4 expression on APCs, which renders them immunosuppressive142. In these ways, TReg cells target both T cells and APCs to create a generally tolerant tumor microenvironment. Increased numbers of TReg cells have been observed in patients with many types of cancer, including pancreatic and breast cancer143, colorectal cancer144, 145, gastric and esophageal cancer146, 147, leukemia and lymphoma148, 149, melanoma150, 151, lung and ovarian cancer145, 152, and hepatocellular carcinoma153.

Immunology 21:903–914 99. Gershon RK, Kondo K (1970) Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 18:723–737 100. Berendt MJ, North RJ (1980) T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor. J Exp Med 151:69–80 101. Bursuker I, North RJ (1984) Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cellmediated suppression of immunity.

Nat Rev Immunol 4:762–774 142. Fallarino F, Grohmann U, Hwang KW, Orabona C, Vacca C, Bianchi R, Belladonna ML et al (2003) Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol 4:1206–1212 143. Wilke CM, Zou W (2011) T lymphocytes to IDO+ cells: check. Blood 117:2082–2083 144. Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M et al (2006) B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med 203:871–881 145.

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Cancer Immunotherapy: Paradigms, Practice and Promise by Tyler J. Curiel (auth.), Tyler J. Curiel (eds.)


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