By Tyler J. Curiel (auth.), Tyler J. Curiel (eds.)
This paintings will offer a historic viewpoint on tumor immunotherapy, speak about basic mechanisms of failed tumor rejection, examine passive options to spice up anti-tumor immunity, in addition to have an in-depth examine energetic suggestions to spice up anti-tumor immunity.
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Extra info for Cancer Immunotherapy: Paradigms, Practice and Promise
Killer (NK), and T cell function133, 134; competitive consumption of the T cell survival factor IL-2119, 135, 136; perforin and granzyme-dependent killing of APCs and T cells137, 138; CTLA-4 induction of indolamine 2,3-dioxygenase (IDO)-expression, which promotes tolerance139–141; and finally induction of B7H4 expression on APCs, which renders them immunosuppressive142. In these ways, TReg cells target both T cells and APCs to create a generally tolerant tumor microenvironment. Increased numbers of TReg cells have been observed in patients with many types of cancer, including pancreatic and breast cancer143, colorectal cancer144, 145, gastric and esophageal cancer146, 147, leukemia and lymphoma148, 149, melanoma150, 151, lung and ovarian cancer145, 152, and hepatocellular carcinoma153.
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Cancer Immunotherapy: Paradigms, Practice and Promise by Tyler J. Curiel (auth.), Tyler J. Curiel (eds.)