By Motomichi Torisu
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Additional resources for Basic Mechanisms and Clinical Treatment of Tumor Metastasis
This necrotic extract-induced detachment was reduced but not completely abrogated by prior exposure of the cells to the lysosome stabilizer hydrocortisone hemisuccinate (Weiss, 1978). Although it is difficult to give definitive explanations of these data, it seems likely that necrotic materials promote cell detachment both by their direct enzymatic activity and by labilizing lysosomes, thereby promoting nonlethal degradation of the pericellular regions. The effects of necrotic extracts from W-256 tumors and Gardner lymphosarcomas have also been studied on the in vitro, transmem brane migration of W-256 and lymphosarcoma cells and rat and mouse peritoneal macrophages (Turner and Weiss, 1980).
Have you examined NK, macrophages, and cytotoxic T cells? KOBAYASHI: Both specific and nonspecific immunity may be involved in explaining the rejection mechanism of virus-infected tumors and the subsequent production of antitumor im munity following regression of the tumor. GOLUB: Have you examined the possible involvement of NK cells or interferon in the viral-infected cell immunotherapy? Are there strain differences in mice and can these be correlated to NK levels? KOBAYASHI: As far as we have tested, it seems that activated NK cells or interferon will not explain the entire mech anism of the strong immunogenicity of tumor cells caused by infection with virus in rats.
Unfortunately, we are un aware of matching data for the other B16 lines used in the experi ments summarized in Table I. It must be emphasized that as all of these tumors metastasize to some extent, invasive failure is rel ative with respect to rate and not an all-or-none phenomenon. IV. , 1980; Recklies and Poole, 1982; Zeidman, 1982). This view may be oversimplistic, as there are dis crepancies between malignancy and normalcy with respect to enzymes; in addition, the physicochemical nature of the stroma represents a balance between degradation and synthesis, and "bystander" cells involved in inflammatory and other responses may play key roles in maintaining or disrupting the connective tissue steady state.
Basic Mechanisms and Clinical Treatment of Tumor Metastasis by Motomichi Torisu